@article{87141, keywords = {Animals, DNA, Static Electricity, Humans, Cytological Techniques}, author = {Sohn and Saleh and Facer and Beavis and Allan and Notterman}, title = {Capacitance cytometry: measuring biological cells one by one.}, abstract = { Measuring the DNA content of eukaryotic cells is a fundamental task in biology and medicine. We have observed a linear relationship between the DNA content of eukaryotic cells and the change in capacitance that is evoked by the passage of individual cells across a 1-kHz electric field. This relationship is species-independent; consequently, we have developed a microfluidic technique-"capacitance cytometry"-that can be used to quantify the DNA content of single eukaryotic cells and to analyze the cell-cycle kinetics of populations of cells. Comparisons with standard flow cytometry demonstrate the sensitivity of this new technique. }, year = {2000}, journal = {Proc Natl Acad Sci U S A}, volume = {97}, pages = {10687-90}, month = {09/2000}, issn = {0027-8424}, doi = {10.1073/pnas.200361297}, language = {eng}, }